PKC-ε-dependent survival signals in diabetic hearts
نویسندگان
چکیده
Ashwani Malhotra, Rebecca Begley, Barinder P. S. Kang, Irmindra Rana, Jing Liu, Guiping Yang, Daria Mochly-Rosen, and Leonard G. Meggs Division of Nephrology, Department of Medicine, and Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey; and Department of Molecular Pharmacology, Stanford University, Stanford, California
منابع مشابه
Changes in cardiac protein kinase C activities and isozymes in streptozotocin-induced diabetes.
To understand cardiac dysfunction in diabetes, the activity of protein kinase C (PKC) and protein contents of its isozymes (PKC-α, -β, -ε, and -ζ) were examined in diabetic rats upon injection of streptozotocin (65 mg/kg iv). The hearts were removed at 1, 2, 4, and 8 wk, and some of the 6-wk diabetic animals had been injected with insulin (3 U/day) for 2 wk. The Ca2+-dependent PKC activity was ...
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